https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47126 Wed 14 Dec 2022 14:45:32 AEDT ]]> Genome-wide association study identifies 74 loci associated with educational attainment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33716 Wed 12 Dec 2018 14:03:45 AEDT ]]> Emerging concepts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19930 Sat 24 Mar 2018 07:58:37 AEDT ]]> Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30267 n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.]]> Sat 24 Mar 2018 07:33:37 AEDT ]]>